This study provides a comprehensive analysis of the thematic evolution within the Asia-Pacific Economic Cooperation (APEC) ministerial meetings from its inception in 1989 to the present, examining over 460 meeting documents. The research employs both quantitative and qualitative methods, including text mining techniques, to uncover primary themes and shifts in policy focus over time. The study is organized into three main areas: first, it investigates the distribution and evolution of agendas across different levels and sectors of APEC meetings. Second, it tracks thematic changes within sector-specific meetings, with a particular emphasis on trade, finance, and small and medium enterprises (SMEs). Third, it explores the interconnections among these meetings to reveal the dynamic relationships within APEC’s framework. The findings indicate a significant increase in the number and diversity of APEC meetings, reflecting an expanded agenda addressing more complex and emerging issues such as the digital economy, sustainable development, and inclusive growth. The study also identifies a shift from foundational economic arrangements to more diversified topics, demonstrating APEC’s adaptability to contemporary global challenges. Additionally, the research highlights the evolving hierarchical structure among meetings, with a growing focus on digital economy and sustainability. This work offers valuable insights for policymakers, scholars, and stakeholders involved in regional economic integration and cooperation, showcasing APEC’s role in addressing both traditional and emerging economic challenges in the Asia-Pacific region.